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We used a Vonoroi diagram to depict drug dose–response data of the GDSC drug–response encyclopaedia, which resulted in a drug atlas. b Relations of drug dose–response data are difficult to comprehend, given the enormous amount of data points associated with them. Hence, in our model, synergy between drugs is expected when pairs of drugs act on independent processes. However, when a third cell line is sensitive to both of these drugs, then these unrelated mechanisms are affected simultaneously, giving rise to a synergistic effect. If two cell lines have mutually exclusive sensitivity to either drug A or B, as shown by the intensity of each diamond, then two independent molecular mechanisms might be causal of this. This indicates that we can accurately predict effective drug combinations with translational value.Ī Schematic representation of drug-atlas approach. Predicted synergies are provided and have been validated in glioblastoma, breast cancer, melanoma and leukemia mouse-models, resulting in therapeutic synergy in 75% of the tested models. By using this strategy, we can uncover potential effective drug combinations on a pan-cancer scale. Our approach enables the prediction of combination-therapy which can be linked to tumor-driving mutations. The drug atlas represents the relations between drug effects and allows to identify independent processes for which the tumor might be particularly vulnerable when attacked by two drugs. For this we used dose-response data from pharmacogenomic encyclopedias and represent these as a drug atlas. Here we present an approach to uncover the efficacy of drug combinations based on the analysis of mono-drug effects. cancer treatments using combinations of drugs with a synergistic effect is attractive but proves to be highly challenging. 17 Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam, the Netherlands.1 Department of Radiation Oncology, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam, the Netherlands. 16 IOTA Pharmaceuticals Ltd, St Johns Innovation Centre, Cowley Road, Cambridge, UK.15 Neurosurgery, Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.14 Radiation Oncology, Academic Medical Center, Amsterdam, the Netherlands.13 Department of Radio-Oncology, Kantonsspital Graubünden, Loëstrasse 170, CH-7000, Chur, Switzerland.12 Department of Computational Biology, The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.11 Department of Radiation Oncology, NYU Langone Health, New York, NY, 10016, USA.10 Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.9 Department of Epidemiology and Biostatistics, Amsterdam UMC, location VUMC, Amsterdam, the Netherlands.8 Center for Experimental Molecular Medicine (CEMM), Laboratory for Experimental Oncology and Radiobiology (LEXOR), Amsterdam UMC, location AMC, Cancer Center, Amsterdam, the Netherlands.7 Department of Hematology, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam, the Netherlands.6 Department of Medical Oncology, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam, the Netherlands.5 Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.4 Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam, the Netherlands.3 Experimental Therapeutics and Molecular Imaging Lab, Neuroscience Center, Neuro-Oncology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.2 Department of Oncogenomics, Academic Medical Center, Amsterdam, the Netherlands.
Randomly powering up the occasional enemy, even granting them skills, taking some fights that were previously mind-numbingly easy and turning them into something to be feared, especially if it happens to be a boss that gets the elite status. Lastly for combat, there are a few elite enemy spawn mods that, in my opinion, are freaking awesome. Meanwhile my armor is sitting at around 5k, while everyone swings for 4k, making it an extremely tactical experience. I empty two quick bars of skills just trying to get through magic armor, and that's assuming they don't use shields up or armor of frost to instantly recover over 10k- which most of them do. Sounds great, but since enemies scale with me (I play on +10 levels) they are all level 36, with astronomical armor values. These pair well with xp reducing mods so that you don't run into the same problem I am currently having: being level 26 in act 1. If you like the grind of combat, there are quite a few leveling mods that take the enemy to your level (or even higher) so that challenge remains. If you love discovering new loot all the time, do not do this one, as you'll get pretty much all the gear you want pretty early and the rest of the game will be boring. This can make or break the fun in the game. Once you do get to modding, there are quite a few mods that cause your gear to level with you. If you play dos2 without it, it is far better just based on quality of life enhancements than the original. The unleashed mod you mentioned changes a lot about the combat of the game, more than just numbers, making it almost as if someone who loved dos2 said "I could write that game better", and did. I beat dos2 about 12 times before I started using mods, and while some of them are great, they offer a lot of changes that can take some getting used to. Vendor Prices, Bartering & Attitude Formula Level Up: Attribute, Skill & Talent Point Breakdown The Quick Questions and Looking for Group Threads exist for a reason, use them. >!This is spoilery!< to get This is spoilery Submissions should relate to Divinity Original Sin or other works of Larian Studios.ĭo not put spoilers in the title of your post and mark your posts. Join up with a friend to play online in co-op and make your own adventures with the powerful RPG toolkit. Gather your party and get ready for a new, back-to-the-roots RPG adventure! Discuss your decisions with companions fight foes in turn-based combat explore an open world and interact with everything and everyone you see. Welcome To The Divinity: Original Sin Subreddit! Looking for a Group to play with? Try this thread || Discussion Overview Emergency contrast enhanced chest computed tomography (CT) showed a pulmonary embolism on bilateral interlobar pulmonary arteries and segmental branches of both lower lobes ( Fig. We had tracheal intubation, infusion of crystalloids and vasopressors, blood component replacement, and other supportive measures. After five minutes of CPR, her cardiac rhythm was changed to a normal sinus rhythm. And her electrocardiogram was showed a pulseless electrical activity. On admission, her blood pressure was unable to be checked. So, immediate cardiopulmonary resuscitation (CPR) was performed by physician of that clinic in the ambulance. On the way to our hospital emergency room, she had stupor mental state and no pulse rate. The next day, she developed a sudden loss of consciousness and a low blood pressure of 70/50 mm Hg, and was transferred to Soonchunhyang University Cheonan Hospital for precise diagnosis and treatment. Key words: Cesarean section Heart arrest Pulmonary embolism PancreatitisĪ healthy 33-year-old female, with a normal antenatal course, underwent the uneventful cesarean section in a primary hospital at 38 weeks of gestation. Here, we report our case with a review of literatures. To our knowledge, our case is one of the most dangerous conditions after the cesarean section. We describe the consideration of amniotic fluid embolism with DIC as most appropriate in this case. She developed acute ischemic pancreatitis after cardiac arrest. Her condition was suitable disseminated intravascular coagulation (DIC). Immediate cardiac compression was performed and eventually resulted in good recovery of her heartbeat. Loss of consciousness occurred one day after cesarean section during her first ambulation. The patient underwent uneventful course on that day. A 33-year-old woman underwent elective repeat cesarean section at 38 weeks of gestation under spinal anesthesia. Obstetrical clinicians have low experience to these serious situations necessitating immediate first aid and knowledge of its differential diagnosis. Maternal treatment is primarily supportive, whereas prompt delivery of the mother who has sustained cardiopulmonary arrest is critical for improved newborn outcome.Cardiac arrest one day after cesarean section is extremely rare. Data regarding the presence of risk factors for amniotic fluid embolism are inconsistent and contradictory at present, no putative risk factor has been identified that would justify modification of standard obstetric practice to reduce the risk of this condition. Clinical series based on population or administrative databases that do not include individual chart review by individuals with expertise in critical care obstetrics are likely to both overestimate the incidence and underestimate the mortality of this condition by the inclusion of women who did not have amniotic fluid embolism. Progress in our understanding of this syndrome continues to be hampered by a lack of universally acknowledged diagnostic criteria, the clinical similarities of this condition to other types of acute critical maternal illness, and the presence of a broad spectrum of disease severity. This response and its subsequent injury appear to involve activation of proinflammatory mediators similar to that seen with the classic systemic inflammatory response syndrome. The pathophysiology appears to involve an abnormal maternal response to fetal tissue exposure associated with breaches of the maternal-fetal physiologic barrier during parturition. Amniotic fluid embolism remains one of the most devastating conditions in obstetric practice with an incidence of approximately 1 in 40,000 deliveries and a reported mortality rate ranging from 20% to 60%. Unless Black Box is aware of the export and has obtained the appropriate U.S. The Customer certifies that (i) the purchase does not require Black Box to export such items, By proceeding with a transaction to purchase any ITAR restricted item(s), Department of State's Directorate of Defense Regulations (ITAR), 22 CFR Chapter 1, Subchapter M, and export is strictly prohibited withoutĪuthorization or a license issued by the U.S. Some Black Box products on this website are subject to the International Traffic in Arms Front-panel LEDs show automatic scanning input and output status.Supports auto EDID function, as well as manual copy for compatibility with every monitor.Remembers the last state during a power cycle. Switch using front-panel buttons, the included IR remote controller.Ĭompatible with all HDMI source devices, PC monitors, plasma HD displays, HDTV, and audio receivers/amplifiers. When used with digital signage, the switch enables you to quickly switch a display from one digital signage source to another. It's ideal for corporate theaters, meeting rooms, classrooms, and broadcasting studios. Ideal for any venue where multiple high-definition displays must be managed Support for Dolby TrueHD, Dolby Digital, Dolby Digital EX, DTS, DTS-HD, DTS-HD Master, DTS-EX, PCM, PCM2, and LPCM2. Plus, it provides support for 19:10 aspect ratio, data rates up to 6.75 Gbps, and 3D formats. It also carries the high-speed digital video signaling of TMDS formats for 10-, 12-, 16-, or 32-bit Deep Color. The switch supports sharp, UHD 4K video and works with wide range of resolutions from PC XGA to WUXGA 1920 x 1200 and HDTV/DTV resolutions 480i/480p, 576i/576p, 720p, 1080i, and 1080p. Each input can be routed to any output, or the same input can be routed to all outputs or any combination, eliminating the need to manually move cables to display HDMI video from different sources on different screens. The 4K 4 x 2 HDMI Matrix Switch provides unrivaled versatility when controlling video and audio output on high-resolution HDMI displays. Il treno parte alle sedici e cinquanta.14:00 = Sono le quattordici … OR … Sono le due.Sometimes a person will say the time giving the 12-hour clock version even if it is given in its 24-hour form. Since we already know how to tell the time with the numbers from 1-12, let’s look at the time with the numbers from 13-23. New York vs London Central vs Eastern Time California vs Hawaii Eastern vs. Time Difference Calculator Popular Converters. For instance, 3:00 pm plus 12 is 1500 hours, and 5:00 pm plus 12. You just say the number ( quindici / trenta). GMT and UTC difference Daylight Saving Time How we keep time in zones Military Time. If the time is 1:00 pm or after, add 12 to the specified hour to get the time in military time. When the 24-hour clock is used, the expressions using quarto and mezzo are not used. This is to avoid any possibility of misunderstanding such as arriving at 8 at night when you were supposed to arrive at 8 in the morning! Military time, also known as 24-hour time, is a time-keeping system used by the military, emergency services, and other organizations around the world. In many countries, this is the standard and is called the 24 hour clock. The first two digits represent hours, and the last two represent the minutes of the 24-hour clock. Military time format consists of four digits, beginning with 0100 and going through 2400 hours. to distinguish between morning and afternoon times, they say 03. It is also called the 24-hour clock, because each hour receives a number designation different from the rest from 1 to 24 beginning. In Italian, it is common to use the 24-hour clock ( sistema delle 24 ore) especially with transport times (plane and train schedules), movie times, concert times or any official time. Some countries in the world use a 24 hour clock. We have already seen how to tell the time in Italian, though this is using the typical 12-hour clock. “With the ball at her feet I think she’s the best player around, and I think she continues to show that every game that we play,” Pope Prep coach Zack Trobaugh said. Her agility makes her a threat to score in most situations she gained speed over the years through playing in boys and girls travel leagues and trying to match her fraternal twin brother. Using quick bursts to race past defenders, Collins rebounded with second-half strikes in the 47th, 57th and 71st minutes. Her 29th goal this season came 21 minutes before halftime, but she struggled early under duress from the back-to-back state champion Hawks (9-4) and all-state defender Bella Henderson. Really it has to do with the players just as much as me.”Ĭollins missed four of Pope Prep’s games while on college visits as a junior but was still named Division II-AA Middle’s Most Valuable Player after leading the Knights to the state quarterfinals. “Shout out to Lauren (Gafney) she made a perfect run off the ball and it was just an easy slot in for me. “They’re really just feeding me the ball,” Collins said after her four-goal performance in the Knights’ 4-0 win. She set the mark last year with 30 goals in 11 games and became the program’s all-time leading scorer in the process. With her third score of the night against Merrol Hyde and the 31st of her senior year, Collins usurped herself in the school record books for the most goals in a single season. Sworn local, state, and federal law enforcement officers attending nonticketed university events (e.g.Cameras meeting designated event standards will be permitted.The Following items are not permitted at Yuengling Center Events: We apologize for any inconvenience this may cause. To help ensure your safety, Yuengling Center has strict security measures designed to help all guests have a safe and enjoyable experience while attending an event at Yuengling Center. For more info, check out /AEW /AEW /AEW /AEW Emi Sakura is the oldest AEW member from the womens wrestling roster. AEW’s multi-platform content also includes “Being the Elite,” a weekly behind-the-scenes YouTube series and “AEW Unrestricted,” a weekly podcast series. The AEW roster is quite diverse, as some wrestlers are 22 and others are almost 60. ET on TNT, and the new “AEW: Collision” airs every Saturday, starting June 17, from 8:00 – 10:00 p.m. The fight-forward “AEW: Rampage” airs every Friday from 10:00 – 11:00 p.m. ET on TBS and attracts the youngest wrestling audience on television. “AEW: Dynamite” airs every Wednesday from 8:00 – 10:00 p.m. Britt Baker, Sting, Darby Allin, Sammy Guevara, Ruby Soho, Jack Perry, Jay White, Christian Cage, Will Hobbs, Ricky Starks, The Acclaimed, Matt & Jeff Hardy, Lucha Bros., Mark Briscoe, Samoa Joe, Keith Lee, Swerve Strickland and many more.įounded by CEO, GM and Head of Creative Tony Khan in 2019, AEW is offering an alternative to mainstream wrestling, with a roster of world-class talent that is injecting new spirit, freshness and energy into the industry. The best of the best from the AEW talent roster means players can look forward to playing as some of the most legendary wrestlers to enter the ring plus all-new, high-flying AEW talent AEW: Fight. AEW’s roster includes headliners such as Chris Jericho, MJF, Kenny Omega, The Young Bucks, Jon Moxley, Bryan Danielson, FTR, Toni Storm, Kris Statlander, Orange Cassidy, Wardlow, Malakai Black, Hangman Adam Page, Claudio Castagnoli, Adam Cole, Jamie Hayter, Saraya, Jade Cargill, Dr. Developed by acclaimed wrestling game developer Yuke’s, AEW Fight Forever is the first video game officially licensed by All Elite Wrestling. ET for an action-packed night of bell-to-bell action.ĪEW’s debut in Tampa will also mark a significant 200-show milestone for “AEW: Dynamite,” which launched in October 2019 and revolutionized the professional wrestling industry. Stars from AEW’s world-class roster will appear live at the Yuengling Center on Wednesday, August 2 at 7:00 p.m. History will be made this summer when AEW’s wildly popular professional wrestling shows, “AEW: Dynamite” and “AEW: Rampage,” make their debut in Tampa. Wednesday’s 1 wrestling show continues to inject new spirit, freshness and energy into to mainstream wrestling. Put the meth in the bowl.Heat a small amount of Methylated Spirits (a glass in the microwave works, just don’t put it on for too long)Meth is quite soluble in Methylated Spirits, so you want to use as little as possible. Knife (or a metal skewer or similar to help break up those stubborn bits) Ideally, you should recrystalise the meth in between acetone washes (and even before the first wash)Ĭlean meth is a white-ish/cloudy crystal that will give off white vapour when heated, and will leave only the smallest residue after it is all vaporized. More acetone washes can be performed if it still looks to be dirty. Just let it sit there, or put it in the sun for a while.It should now be relatively clean. You can pour it off into another bowl and then do more acetone washes on it if you want. A small amount of meth will be in the acetone. A minute or so will be fine.Tip the bowl onto an angle and swish it around so that all of the meth is together in a corner.Let it settle out for a short while, then SLOWLY tip the bowl around so that the meth stays in the corner and the acetone drains off and is now on the other side of the bowl.The acetone can be poured off or you can leave the bowl propped up on an angle and let it evaporate. So try to do it quickly, but don’t hurry and fuck it up. You’ll obviously need more if your bowl has a larger surface area.Swish the bowl around and then use the knife to break up any larger bits of impurities.The less time the meth sits in the acetone, the less chance it will have of getting dissolved. (The water dissolves the meth) 30-50mL is usually enough for ½-1gram. You want enough that it can dissolve all the impurities, but the acetone potentially contains water, which means lost meth. Put the Meth in bowl.Add the cold acetone. Not too wide either, 4inch is a good size) Ideally, use the acetone soon, to avoid it re-absorbing more moisture.īowl (ideally glass, shallow & with straight sides. Pour the Epsom salts into the acetone and mix them around.įilter the acetone through the filter paper. (This is to dry any moisture out of them) Put some of the Epsom salts on a tray in the oven for an hour or so on at least 130 degrees Centigrade. Though the older it is the greater the chance it has absorbed moisture from the air. Most acetone that you’ll buy will be dry enough to use for washing. (Lots of small crystals means larger surface area, which means larger chance of the acetone dissolving the meth… especially if the acetone isn’t really dry. The reason this is good is if you have a large crystal with the crap on the outside, when the acetone is added it will dissolve the impurities and wont have as great a chance to dissolve your meth. As a bonus, the impurities usually grow on the outside of the meth crystal. The slower the crystals form, the larger they will be. If you want to wash your meth really well, then ideally, you’ll need to recrystalise it as well. (freebase it then convert it back to its salt form) So if you know that it has glucose in it, don’t bother… if you really want to clean it you must A/B. Unfortunately, glucose (or sugar) is one of the ones that it won’t remove. You can get everything over-the-counter… except the meth You can also do it using a coffee filter, but I’ve found that yields suffer due to meth getting caught in the filter.Īcetone will remove MOST impurities, but some will get through. Solubility less than 1 mg/mL at 72 ° F (NTP, 1992) Sol in methyl acetate, isobutyl alcohol practically insol in petroleum naphtha, xylene SOL IN PYRIDINE, ETHYL ACETATE 42.7 g/100 g acetone 23 deg C 54.4 g/100 g ethyl alcohol 23 deg C 10.45 g/100 g isobutyl carbinol 23 deg C 9.61 g/100 g isopropyl alcohol 23 deg C 9.43 g/100 g methyl ethyl ketone 23 deg C 3.76 g/100 g isoamyl acetate 23 deg C 0.49 g/100 g diethyl ether 23 deg C 0.03 g/100 g mineral spirits 23 deg C 90 g/100 g water 20 deg C Soluble in less than its own weight of water very soluble in hydrochloric acid (dilute or concn) soluble in a.Quite a few people have been asking about washing meth, so here’s one of the easiest (IMHO) ways to go about it. 77864 Stannous dichloride tin(II)dichloride KS-00000UI2 STANNOUSCHLORIDE CCRIS 560 Tin(II) chloride, LR, >=98% Tin(II) chloride, >=99.99% trace metals basis. Alternative Name: Tin(II) chloride, Vetec(TM) reagent grade, 98% C.I. it is used for color retention in asparagus at less than 20 ppm. it reacts read- ily with oxygen, preventing its combination with chemicals and foods which would otherwise result in discoloration and undesirable odors. Stannous Chloride is an antioxidant and preservative that exists as white or colorless crystals, being very soluble in water. Quick inquiry Where to buy Suppliers range Moreover, the HT2150ST handles average ambient lighting conditions pretty well. You can find out how to avoid them below. Keeping the price of the BenQ HT2150ST, there are some noticeable features, such as RGBRGB color wheel, different color modes, short-throw projection, 3D viewing, and low input lag for gaming. These cookies and other technologies capture data like your IP address, when you viewed the page or email, what device you were using and where you were. 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These cookies help to improve the performance of BenQ. Performance cookies and advertising cookies 2200 Lumens, 7.9 lbs, DLP HD 1080 Projector. |
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